Cai Jiang

Apr 29, 2024 | onlinelibrary.wiley.com | Cong Chen |Cai Jiang |Ting Lin |Yue Hu

1 INTRODUCTION Type 2 diabetes mellitus (T2DM), characterized primarily by insulin resistance (IR) and hyperglycemia, is a critical risk factor for impaired physical and mental health.

Jan 29, 2024 | biorxiv.org | Li Niu |Jinnan Hu |Chuan Chen |Cai Jiang

AbstractSequencing clinical liquid biopsy, especially circulating tumor DNA (ctDNA), provides a valuable method for identifying low allele frequency tumor variants, opening novel clinical applications, particularly in treatment selection for late-stage cancer patients. Despite advancements, challenges in assay development persist, primarily due to limited sample volumes and insufficiency of reads supporting low allele frequency variants.

Jan 13, 2024 | biorxiv.org | Jinnan Hu |Cai Jiang |Yu Huang |Haodong Chen

AbstractLiquid biopsy enables identification of low allele frequency (AF) tumor variants and novel clinical applications such as minimum residual disease (MRD) monitoring. However, challenges remain, primarily due to limited sample volume and low read count of low-AF variants. Because of the low AFs, some clinically significant variants are difficult to distinguish from errors introduced by PCR amplification and sequencing.