Can Cao

May 24, 2024 | nature.com | Yoojoong Kim |Yongfeng Liu |Can Cao |Brian Krumm |Manish Jain |Shicheng Zhang | +1 more

Correction to: Nature https://doi.org/10.1038/s41586-024-07253-y Published online 10 April 2024In the version of the article initially published, the locations of residues in TM6 were incorrectly shifted by one helical turn in Figs. 2b, 2c, 3b, 3d, 4f, Extended Figs. 3o, 3p, 4a, 7a, 7b, 9c–h and Extended Data Table 1. These figures and the Extended Data have now been updated to amend this error (see the Supplementary Information for a list of edits and original article for comparison).

Apr 10, 2024 | nature.com | Yoojoong Kim |Yongfeng Liu |Can Cao |Brian Krumm |Manish Jain |Shicheng Zhang | +1 more

AbstractBitter taste sensing is mediated by type 2 taste receptors (TAS2Rs (also known as T2Rs)), which represent a distinct class of G-protein-coupled receptors1. Among the 26 members of the TAS2Rs, TAS2R14 is highly expressed in extraoral tissues and mediates the responses to more than 100 structurally diverse tastants2,3,4,5,6, although the molecular mechanisms for recognizing diverse chemicals and initiating cellular signalling are still poorly understood.

Apr 10, 2024 | onlinelibrary.wiley.com | Can Cao |Shaobo Ji |Ying Jiang |Jiangtao Su

Supporting Information Filename Description adma202401875-sup-0001-SuppMat.pdf6.9 MB Supporting Information adma202401875-sup-0001-VideoS1.mp44.6 MB Supplemental Video 1 adma202401875-sup-0002-VideoS3.mp46.2 MB Supplemental Video 2

Mar 2, 2023 | cell.com | Can Cao |Bryan Roth

Enhanced excitability of MRGPRA3- and MRGPRD-positive nociceptors in a model of inflammatory itch and pain. Brain. 2014; 137: 1039-1050Pruriception and neuronal coding in nociceptor subtypes in human and nonhuman primates. eLife. 2021; 10e64506Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains. Cell. 1986; 45: 711-719A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Cell.