Brian Krumm

Aug 4, 2024 | nature.com | Kevin Knight |Brian Krumm |W. Grant Ludlam |Meng Cui |Tyler J. Lefevre |Wenyuan Wei | +9 more

AbstractMany neurotransmitter receptors activate G proteins through exchange of GDP for GTP. The intermediate nucleotide-free state has eluded characterization, due largely to its inherent instability. Here we characterize a G protein variant associated with a rare neurological disorder in humans. GαoK46E has a charge reversal that clashes with the phosphate groups of GDP and GTP.

May 24, 2024 | nature.com | Yoojoong Kim |Yongfeng Liu |Can Cao |Brian Krumm |Manish Jain |Shicheng Zhang | +1 more

Correction to: Nature https://doi.org/10.1038/s41586-024-07253-y Published online 10 April 2024In the version of the article initially published, the locations of residues in TM6 were incorrectly shifted by one helical turn in Figs. 2b, 2c, 3b, 3d, 4f, Extended Figs. 3o, 3p, 4a, 7a, 7b, 9c–h and Extended Data Table 1. These figures and the Extended Data have now been updated to amend this error (see the Supplementary Information for a list of edits and original article for comparison).

Apr 10, 2024 | nature.com | Yoojoong Kim |Yongfeng Liu |Can Cao |Brian Krumm |Manish Jain |Shicheng Zhang | +1 more

AbstractBitter taste sensing is mediated by type 2 taste receptors (TAS2Rs (also known as T2Rs)), which represent a distinct class of G-protein-coupled receptors1. Among the 26 members of the TAS2Rs, TAS2R14 is highly expressed in extraoral tissues and mediates the responses to more than 100 structurally diverse tastants2,3,4,5,6, although the molecular mechanisms for recognizing diverse chemicals and initiating cellular signalling are still poorly understood.