Yongfeng Liu

May 24, 2024 | nature.com | Yoojoong Kim |Yongfeng Liu |Can Cao |Brian Krumm |Manish Jain |Shicheng Zhang | +1 more

Correction to: Nature https://doi.org/10.1038/s41586-024-07253-y Published online 10 April 2024In the version of the article initially published, the locations of residues in TM6 were incorrectly shifted by one helical turn in Figs. 2b, 2c, 3b, 3d, 4f, Extended Figs. 3o, 3p, 4a, 7a, 7b, 9c–h and Extended Data Table 1. These figures and the Extended Data have now been updated to amend this error (see the Supplementary Information for a list of edits and original article for comparison).

Apr 10, 2024 | nature.com | Yoojoong Kim |Yongfeng Liu |Can Cao |Brian Krumm |Manish Jain |Shicheng Zhang | +1 more

AbstractBitter taste sensing is mediated by type 2 taste receptors (TAS2Rs (also known as T2Rs)), which represent a distinct class of G-protein-coupled receptors1. Among the 26 members of the TAS2Rs, TAS2R14 is highly expressed in extraoral tissues and mediates the responses to more than 100 structurally diverse tastants2,3,4,5,6, although the molecular mechanisms for recognizing diverse chemicals and initiating cellular signalling are still poorly understood.

Dec 6, 2023 | nature.com | Stefan Gahbauer |Joao M. Braz |Hye Jin Kang |Christian B. Billesbølle |Yongfeng Liu |Tao Che | +7 more

AbstractThe lipid prostaglandin E2 (PGE2) mediates inflammatory pain by activating G protein-coupled receptors, including the prostaglandin E2 receptor 4 (EP4R). Nonsteroidal anti-inflammatory drugs (NSAIDs) reduce nociception by inhibiting prostaglandin synthesis, however, the disruption of upstream prostanoid biosynthesis can lead to pleiotropic effects including gastrointestinal bleeding and cardiac complications.