Candice Kutchukian

Oct 13, 2023 | cell.com | Maria Ximena Casas |María Casas |Candice Kutchukian |Sara Sanchez |Jonathan D. Horvath

Highlights•α-Syn fibrils facilitate ARF6-PIP5K1γ increases in PI(4,5)P2•α-Syn-driven increases in PI(4,5)P2 represent a key proximal step in α-Syn aggregation•α-Syn elevations in PI(4,5)P2 increase mitochondrial Ca2+ to drive neuronal cytotoxicitySummaryAnomalous aggregation of α-synuclein (α-Syn) is a pathological hallmark of many degenerative synucleinopathies including Lewy body dementia (LBD) and Parkinson’s disease (PD).