Sara Sanchez

Oct 18, 2023 | nature.com | Antonietta Capotondi |Shayne McGregor |Michael J. McPhaden |Sophie E. CRAVATTE |Neil Holbrook |Sara Sanchez | +18 more

AbstractNaturally occurring tropical Pacific variations at timescales of 7–70 years — tropical Pacific decadal variability (TPDV) — describe basin-scale sea surface temperature (SST), sea-level pressure and heat content anomalies. Several mechanisms are proposed to explain TPDV, which can originate through oceanic processes, atmospheric processes or as an El Niño/Southern Oscillation (ENSO) residual.

Oct 13, 2023 | cell.com | Maria Ximena Casas |María Casas |Candice Kutchukian |Sara Sanchez |Jonathan D. Horvath

Highlights•α-Syn fibrils facilitate ARF6-PIP5K1γ increases in PI(4,5)P2•α-Syn-driven increases in PI(4,5)P2 represent a key proximal step in α-Syn aggregation•α-Syn elevations in PI(4,5)P2 increase mitochondrial Ca2+ to drive neuronal cytotoxicitySummaryAnomalous aggregation of α-synuclein (α-Syn) is a pathological hallmark of many degenerative synucleinopathies including Lewy body dementia (LBD) and Parkinson’s disease (PD).