Maria Ximena Casas
Articles
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Oct 13, 2023 |
cell.com | Maria Ximena Casas |María Casas |Candice Kutchukian |Sara Sanchez |Jonathan D. Horvath
Highlights•α-Syn fibrils facilitate ARF6-PIP5K1γ increases in PI(4,5)P2•α-Syn-driven increases in PI(4,5)P2 represent a key proximal step in α-Syn aggregation•α-Syn elevations in PI(4,5)P2 increase mitochondrial Ca2+ to drive neuronal cytotoxicitySummaryAnomalous aggregation of α-synuclein (α-Syn) is a pathological hallmark of many degenerative synucleinopathies including Lewy body dementia (LBD) and Parkinson’s disease (PD).
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Jul 28, 2023 |
nature.com | Maria Ximena Casas |María Casas |Sergi Simó |James S. Trimmer |Rose E. Dixon
AbstractLysosomes communicate through cholesterol transfer at endoplasmic reticulum (ER) contact sites. At these sites, the Niemann Pick C1 cholesterol transporter (NPC1) facilitates the removal of cholesterol from lysosomes, which is then transferred to the ER for distribution to other cell membranes. Mutations in NPC1 result in cholesterol buildup within lysosomes, leading to Niemann-Pick Type C (NPC) disease, a progressive and fatal neurodegenerative disorder.
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Aug 28, 2018 |
infobae.com | Maria Ximena Casas
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Aug 11, 2018 |
infobae.com | Maria Ximena Casas
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Jun 3, 2018 |
infobae.com | Maria Ximena Casas
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