Carol Tamminga

2 weeks ago | biologicalpsychiatryjournal.com | Emily Dumas |Jenna Brown |Carol Tamminga |Elena I Ivleva

Certain antipsychotic medications, particularly clozapine, are associated with decreases in the differences in white matter microstructure, cognitive performance, and symptoms typical in psychosis syndromes.

Oct 18, 2024 | psiquiatria.com | Carol Tamminga

Las enfermedades mentales graves, como la psicosis y la manía, representan un grupo complejo y poco comprendido de trastornos cerebrales. Los diagnósticos convencionales de estas afecciones carecen de una base sólida de conocimiento que permita una comprensión profunda de su naturaleza, lo que ha dificultado enormemente el avance en el descubrimiento y desarrollo de tratamientos efectivos.

Jun 13, 2024 | nature.com | Giuseppina Di Salvo |Flurin Cathomas |Emily Newman |Caroline Menard |Li Shen |Carol Tamminga | +1 more

AbstractMood disorders are an enigmatic class of debilitating illnesses that affect millions of individuals worldwide. While chronic stress clearly increases incidence levels of mood disorders, including major depressive disorder (MDD), stress-mediated disruptions in brain function that precipitate these illnesses remain largely elusive.

Feb 12, 2024 | biologicalpsychiatryjournal.com | Carol Tamminga

It was our early studies that noted hippocampal hyperactivity in people with active psychosis which impressed me with the potential role of this brain region in psychosis, especially given its primary function in memory. Our initial laboratory studies focused on excitatory and inhibitory biomarker signals in human postmortem hippocampus by subfield in schizophrenia (SZ) and healthy control (HC), which identified evidence of dentate gyrus (DG) failure and CA3/CA1 hyperactivity.