Giuseppina Di Salvo

Jan 8, 2025 | nature.com | Qingfei Zheng |Shuai Zhao |Stephanie Stransky |Giuseppina Di Salvo |Jinghua Wu |Lauren E Vostal | +8 more

AbstractHistone H3 monoaminylations at Gln5 represent an important family of epigenetic marks in brain that have critical roles in permissive gene expression1,2,3. We previously demonstrated that serotonylation4,5,6,7,8,9,10 and dopaminylation9,11,12,13 of Gln5 of histone H3 (H3Q5ser and H3Q5dop, respectively) are catalysed by transglutaminase 2 (TG2), and alter both local and global chromatin states.

Jun 13, 2024 | nature.com | Giuseppina Di Salvo |Flurin Cathomas |Emily Newman |Caroline Menard |Li Shen |Carol Tamminga | +1 more

AbstractMood disorders are an enigmatic class of debilitating illnesses that affect millions of individuals worldwide. While chronic stress clearly increases incidence levels of mood disorders, including major depressive disorder (MDD), stress-mediated disruptions in brain function that precipitate these illnesses remain largely elusive.