Adam X. Maihofer

Jan 24, 2025 | digitalcommons.library.tmc.edu | Jonas Bybjerg-Grauholm |Peter Roy-Byrne |Caroline M Nievergelt |Adam X. Maihofer

KeywordsHumans, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Neurobiology, Polymorphism, Single Nucleotide, Stress Disorders, Post-Traumatic, White People, White, Black or African American, American Indian or Alaska NativeAbstractPost-traumatic stress disorder (PTSD) genetics are characterized by lower discoverability than most other psychiatric disorders. The contribution to biological understanding from previous genetic studies has thus been limited.

Dec 18, 2024 | genomemedicine.biomedcentral.com | Seyma Katrinli |Agaz Wani |Adam X. Maihofer |Andrew Ratanatharathorn |Nikolaos P. Daskalakis |Janitza L. Montalvo-Ortiz | +7 more

The study includes 2156 current PTSD cases and 2921 trauma-exposed controls from 9 civilian cohorts: BEAR, DNHS, DCHS, GTP, NIU, Shared Roots, AURORA, H3A_Rwanda, WTC; and 9 military cohorts: GMRFQUT, MRS, PRISMO, Army STARRS, PROGrESS, NCPTSD/TRACTS, INTRuST, and VA cohorts (VA-M-AA and VA-M-EA). For DNHS, GTP, MRS, PRISMO, and Army STARRS, two different datasets were available based on the DNAm array.

Aug 27, 2024 | biorxiv.org | Jessica Honorato-Mauer |Nirav Shah |Adam X. Maihofer |Clement C Zai

AbstractIn recent years, significant efforts have been made to improve methods for genomic studies of admixed populations using Local Ancestry Inference (LAI). Accurate LAI is crucial to ensure downstream analyses reflect the genetic ancestry of research participants accurately.

Jul 15, 2024 | medrxiv.org | Seyma Katrinli |Agaz Wani |Adam X. Maihofer |Andrew Ratanatharathorn

CYC is an employee of Biogen. NPD has served on scientific advisory boards for BioVie Pharma, Circular Genomics and Sentio Solutions for unrelated work. NRN serves as an unpaid member of the Ilumivu advisory board. SAMR receives support from the Wounded Warrior Project (WWP), Department of Veterans Affairs (VA), National Institute of Health (NIH), McCormick Foundation, Tonix Pharmaceuticals, Woodruff Foundation, and Department of Defense (DOD).

Mar 31, 2024 | nature.com | Adam X. Maihofer |Vasiliki Michopoulos |Renato Polimanti |Soraya Seedat |Elizabeth Mikita |Alicia Smith | +5 more

AbstractObservational studies suggest that posttraumatic stress disorder (PTSD) increases risk for various autoimmune diseases. Insights into shared biology and causal relationships between these diseases may inform intervention approaches to PTSD and co-morbid autoimmune conditions. We investigated the shared genetic contributions and causal relationships between PTSD, 18 autoimmune diseases, and 3 immune/inflammatory biomarkers.