Caroline Uhler

1 month ago | broadinstitute.org | Adam Zewe |fei chen |Caroline Uhler

A protein located in the wrong part of a cell can contribute to several diseases, such as Alzheimer’s, cystic fibrosis, and cancer. But there are about 70,000 different proteins and protein variants in a single human cell, and since scientists can typically only test for a handful in one experiment, it is extremely costly and time-consuming to identify proteins’ locations manually.

Jan 27, 2025 | nature.com | Hannah Schlüter |Caroline Uhler

AbstractRecent barcoding technologies allow reconstructing lineage trees while capturing paired single-cell RNA-sequencing (scRNA-seq) data. Such datasets provide opportunities to compare gene expression memory maintenance through lineage branching and pinpoint critical genes in these processes.

Oct 15, 2024 | einpresswire.com | Caroline Uhler

Though his focus shifted over time, being a scientist was always the plan for Eric Brown since kindergarten. "First it was dinosaurs and whales, and then it turned into birds, and then it turned into microbes," he said. Years later, Brown began studying structural biology as an undergraduate student at the University of Guelph in Ontario, Canada.

Oct 15, 2024 | broadinstitute.org | Ari Navetta |Ramnik Xavier |Clary B. Clish |Caroline Uhler

Though his focus shifted over time, being a scientist was always the plan for Eric Brown since kindergarten. “First it was dinosaurs and whales, and then it turned into birds, and then it turned into microbes,” he said. Years later, Brown began studying structural biology as an undergraduate student at the University of Guelph in Ontario, Canada.

Jun 3, 2024 | arxiv.org | Jiaqi Zhang |Caroline Uhler