Clary B. Clish

Oct 15, 2024 | broadinstitute.org | Ari Navetta |Ramnik Xavier |Clary B. Clish |Caroline Uhler

Though his focus shifted over time, being a scientist was always the plan for Eric Brown since kindergarten. “First it was dinosaurs and whales, and then it turned into birds, and then it turned into microbes,” he said. Years later, Brown began studying structural biology as an undergraduate student at the University of Guelph in Ontario, Canada.

Sep 18, 2024 | nature.com | Munehiro Furuichi |Takaaki Kawaguchi |Keiko Yasuma-Mitobe |Damian R. Plichta |Masahiro Ueda |Nobuyuki Okahashi | +10 more

AbstractPersistent colonization and outgrowth of potentially pathogenic organisms in the intestine can result from long-term antibiotic use or inflammatory conditions, and may perpetuate dysregulated immunity and tissue damage1,2. Gram-negative Enterobacteriaceae gut pathobionts are particularly recalcitrant to conventional antibiotic treatment3,4, although an emerging body of evidence suggests that manipulation of the commensal microbiota may be a practical alternative therapeutic strategy5,6,7.

Aug 12, 2024 | nature.com | Fenglei Wang |Anne-Julie Tessier |Zhendong Mei |Danielle E. Haslam |Marta Guasch-Ferré |Deirdre K Tobias | +7 more

AbstractDietary haem iron intake is linked to an increased risk of type 2 diabetes (T2D), but the underlying plasma biomarkers are not well understood. We analysed data from 204,615 participants (79% females) in three large US cohorts over up to 36 years, examining the associations between iron intake and T2D risk. We also assessed plasma metabolic biomarkers and metabolomic profiles in subsets of 37,544 (82% females) and 9,024 (84% females) participants, respectively.

Apr 28, 2024 | nature.com | Long Nguyen |Long Nguyễn |Clary B. Clish |Curtis Huttenhower

AbstractThe etiopathogenesis of diverticulitis, among the most common gastrointestinal diagnoses, remains largely unknown. By leveraging stool collected within a large prospective cohort, we performed shotgun metagenomic sequencing and untargeted metabolomics profiling among 121 women diagnosed with diverticulitis requiring antibiotics or hospitalizations (cases), matched to 121 women without diverticulitis (controls) according to age and race.

Dec 5, 2023 | nature.com | Stephanie Collins |Pedro Belda-Ferre |Hsueh-Han Lu |Julian Avila-Pacheco |Damian R. Plichta |Mingxun Wang | +9 more

AbstractDetermining the structure and phenotypic context of molecules detected in untargeted metabolomics experiments remains challenging. Here we present reverse metabolomics as a discovery strategy, whereby tandem mass spectrometry spectra acquired from newly synthesized compounds are searched for in public metabolomics datasets to uncover phenotypic associations.