Catalina Abad

Jun 26, 2024 | nature.com | Catalina Abad |Iago Pinal-Fernandez |Gwladys Bourdenet |Léa Debrut |Sophie Bernard |Andrew L. Mammen

AbstractIdiopathic inflammatory myopathies (IIMs) are severe autoimmune diseases with poorly understood pathogenesis and unmet medical needs. Here, we examine the role of interferon γ (IFNγ) using NOD female mice deficient in the inducible T cell co-stimulator (Icos), which have previously been shown to develop spontaneous IFNγ-driven myositis mimicking human disease. Using muscle proteomic and spatial transcriptomic analyses we reveal profound myofiber metabolic dysregulation in these mice.