Léa Debrut

Jun 26, 2024 | nature.com | Catalina Abad |Iago Pinal-Fernandez |Gwladys Bourdenet |Léa Debrut |Sophie Bernard |Andrew L. Mammen

AbstractIdiopathic inflammatory myopathies (IIMs) are severe autoimmune diseases with poorly understood pathogenesis and unmet medical needs. Here, we examine the role of interferon γ (IFNγ) using NOD female mice deficient in the inducible T cell co-stimulator (Icos), which have previously been shown to develop spontaneous IFNγ-driven myositis mimicking human disease. Using muscle proteomic and spatial transcriptomic analyses we reveal profound myofiber metabolic dysregulation in these mice.

Mar 20, 2024 | nature.com | Margherita Giannini |Léa Debrut

We read with great interest the Review article by Khoo et al. (Epidemiology of the idiopathic inflammatory myopathies, Nat. Rev. Rheumatol. 19, 695–712 (2023))1 and would like to point out findings not included in the Review that shed new light on the epidemiology of idiopathic inflammatory myopathies (IIMs) and future research agendas.