Catrien Bijleveld

Feb 23, 2024 | biorxiv.org | Catrien Bijleveld |Dorret I. Boomsma |Jenny van Dongen |Bodine M.A. Gonggrijp

AbstractWe aimed to understand the long-term impact of negative life events (NLE) on epigenetic aging in 1,808 adults from the Netherlands Twin Register, analyzing five epigenetic biomarkers (Hannum, Horvath, PhenoAge, GrimAge, DunedinPACE) and a series of NLE, including victimization and economic hardship. In population-level analyses, associations between a higher number of NLE (particularly financial adversities, sexual crimes, and job loss) were seen for GrimAge and DunedinPACE biomarkers.