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1 month ago | 
nature.com | Samvida Venkatesh |Duncan Palmer |Nikolas Baya |Melody Parker |Mie T Bruun |Christian Erikstrup | +29 more
AbstractGenome-wide association studies (GWASs) may help inform the etiology of infertility. Here, we perform GWAS meta-analyses across seven cohorts in up to 42,629 cases and 740,619 controls and identify 25 genetic risk loci for male and female infertility. We additionally identify up to 269 genetic loci associated with follicle-stimulating hormone, luteinizing hormone, estradiol and testosterone through sex-specific GWAS meta-analyses (n = 6,095–246,862).
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Oct 30, 2024 | 
nature.com | Bette Loef |Marian Beekman |Dorret I. Boomsma |M. Arfan Ikram |Annemarie Koster |Frits R Rosendaal
AbstractObesity may affect an individual’s immune response and subsequent risk of infection, such as a SARS-CoV-2 infection. It is less clear whether overweight and long-term obesity also constitute risk factors. We investigated the association between the degree and duration of overweight and obesity and SARS-CoV-2 infection.
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Oct 16, 2024 | 
mdpi.com | Maartje Zelis |Dorret I. Boomsma |Linde van Lee |Erik H Serné
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Jun 25, 2024 | 
dialnet.unirioja.es | Anouk den Braber |Diederick Stoffers |Klaus Hansen |Dorret I. Boomsma
den Braber, Anouk[1];van ‘t Ent, Dennis[1];Stoffers, Diederick[2];Linkenkaer-Hansen, Klaus[3];I. Boomsma, Dorret[1];J.C. de Geus, Eco[1][1]Department of Biological Psychology, VU University Amsterdam, The Netherlands. [2]Department of Sleep and Cognition, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands. [3]Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, The Netherlands.
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Mar 27, 2024 | 
nature.com | Nora I. Strom |Christie L. Burton |René Pool |James J. Crowley |Jouke-Jan Hottenga |Henrik R. Larsson | +6 more
AbstractWhile 1–2% of individuals meet the criteria for a clinical diagnosis of obsessive-compulsive disorder (OCD), many more (~13–38%) experience subclinical obsessive-compulsive symptoms (OCS) during their life.
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Mar 6, 2024 | 
nature.com | Minna K. Karjalainen |Eeva Sliz |Elias Allara |Weihua Zhang |Pekka Jousilahti |Kati Kristiansson | +46 more
AbstractGenome-wide association analyses using high-throughput metabolomics platforms have led to novel insights into the biology of human metabolism1,2,3,4,5,6,7. This detailed knowledge of the genetic determinants of systemic metabolism has been pivotal for uncovering how genetic pathways influence biological mechanisms and complex diseases8,9,10,11.
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Feb 23, 2024 | 
biorxiv.org | Catrien Bijleveld |Dorret I. Boomsma |Jenny van Dongen |Bodine M.A. Gonggrijp
AbstractWe aimed to understand the long-term impact of negative life events (NLE) on epigenetic aging in 1,808 adults from the Netherlands Twin Register, analyzing five epigenetic biomarkers (Hannum, Horvath, PhenoAge, GrimAge, DunedinPACE) and a series of NLE, including victimization and economic hardship. In population-level analyses, associations between a higher number of NLE (particularly financial adversities, sexual crimes, and job loss) were seen for GrimAge and DunedinPACE biomarkers.
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Dec 3, 2023 | 
nature.com | Elsje van Bergen |Dorret I. Boomsma
AbstractThe non-cognitive skills self-control and grit are often considered predictors of school performance, but whether this relationship is causal remains unclear. We investigated the causality of this association using a twin design. Specifically, we evaluated the direct impact of self-control and grit on school performance, while controlling for genetic or environmental influences common to all three traits (i.e., confounding).
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Nov 6, 2023 | 
nature.com | Fang Fang |Bryan C Quach |Jesse Marks |Veronika V. Odintsova |Yujing Xia |Laura J. Bierut | +7 more
AbstractCannabis is widely used worldwide, yet its links to health outcomes are not fully understood. DNA methylation can serve as a mediator to link environmental exposures to health outcomes. We conducted an epigenome-wide association study (EWAS) of peripheral blood-based DNA methylation and lifetime cannabis use (ever vs. never) in a meta-analysis including 9436 participants (7795 European and 1641 African ancestry) from seven cohorts.
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Oct 4, 2023 | 
nature.com | Ashley Budu-Aggrey |Anna Kilanowski |Maria K Sobczyk |Suyash Shringarpure |Ruth E. Mitchell |Kadri Reis | +68 more
AbstractAtopic dermatitis (AD) is a common inflammatory skin condition and prior genome-wide association studies (GWAS) have identified 71 associated loci. In the current study we conducted the largest AD GWAS to date (discovery N = 1,086,394, replication N = 3,604,027), combining previously reported cohorts with additional available data.
