Jenny van Dongen

Feb 23, 2024 | biorxiv.org | Catrien Bijleveld |Dorret I. Boomsma |Jenny van Dongen |Bodine M.A. Gonggrijp

AbstractWe aimed to understand the long-term impact of negative life events (NLE) on epigenetic aging in 1,808 adults from the Netherlands Twin Register, analyzing five epigenetic biomarkers (Hannum, Horvath, PhenoAge, GrimAge, DunedinPACE) and a series of NLE, including victimization and economic hardship. In population-level analyses, associations between a higher number of NLE (particularly financial adversities, sexual crimes, and job loss) were seen for GrimAge and DunedinPACE biomarkers.

Nov 6, 2023 | biorxiv.org | Ayşe Demirkan |Jenny van Dongen |Casey T. Finnicum |Harm Jan Westra

AbstractBoth gene methylation and the gut microbiome are partially determined by host genetics and partially by environment. We investigated the relations between gene methylation in blood and the abundance of common gut bacteria profiled by 16s rRNA gene sequencing in two population based Dutch cohorts: LifeLinesDeep (LLD, n = 616, discovery) and the Netherlands Twin Register (NTR, n = 296, replication).

Aug 10, 2023 | elifesciences.org | Jenny van Dongen |Gonneke Willemsen |Dorret I. Boomsma |Michael C. Neale

Accepted manuscript, PDF only. Full online edition to follow. Author Accepted Manuscript PDF only version. The full online version will follow soon. Accepted Manuscript publishedAugust 10, 2023 (This version) AcceptedAugust 8, 2023 ReceivedSeptember 6, 2022 Share this article Cite this article Effects of smoking on genome-wide DNA methylation profiles: A study of discordant and concordant monozygotic twin pairs eLife 12:e83286.