Catriona A. Ford

Aug 29, 2023 | biorxiv.org | Sigrid K Fey |Arafath K. Najumudeen |Catriona A. Ford |Kathryn L. Gilroy

AbstractPancreatic cancer is characterised by the prevalence of oncogenic mutations in KRAS. Previous studies have reported that altered Kras gene dosage drives progression and metastatic incidence in pancreatic cancer. While the role of oncogenic KRAS mutation is well characterised, the relevance of the partnering wild-type KRAS allele in pancreatic cancer is less well understood and controversial.

Aug 14, 2023 | nature.com | Johan Vande Voorde |Rory T. Steven |Arafath K. Najumudeen |Chelsea J. Nikula |Yuchen Xiang |Lauren Ford | +22 more

AbstractThe genomic landscape of colorectal cancer (CRC) is shaped by inactivating mutations in tumour suppressors such as APC, and oncogenic mutations such as mutant KRAS. Here we used genetically engineered mouse models, and multimodal mass spectrometry-based metabolomics to study the impact of common genetic drivers of CRC on the metabolic landscape of the intestine.