Céline Moriou

Jan 10, 2025 | nature.com | Tilman Schneider-Poetsch |Yuichi Shichino |Céline Moriou |Daniel Romo |Jun Liu |Takuhiro Ito | +3 more

AbstractNatural products have a long history of providing probes into protein biosynthesis, with many of these compounds serving as therapeutics. The marine natural product girolline has been described as an inhibitor of protein synthesis. Its precise mechanism of action, however, has remained unknown. The data we present here suggests that girolline is a sequence-selective modulator of translation factor eIF5A.