Takuhiro Ito

Jan 10, 2025 | nature.com | Tilman Schneider-Poetsch |Yuichi Shichino |Céline Moriou |Daniel Romo |Jun Liu |Takuhiro Ito | +3 more

AbstractNatural products have a long history of providing probes into protein biosynthesis, with many of these compounds serving as therapeutics. The marine natural product girolline has been described as an inhibitor of protein synthesis. Its precise mechanism of action, however, has remained unknown. The data we present here suggests that girolline is a sequence-selective modulator of translation factor eIF5A.

Nov 8, 2023 | nature.com | Takuhiro Ito

The integrated stress response affects cell survival or death under stress conditions, and depends on the activity of the eukaryotic translation initiation factor eIF2B. New research identifies a protein helix that modulates this response by controlling the structural states of eIF2B. The integrated stress response (ISR) is a highly conserved translational control mechanism in eukaryotes that detects, and enables adaptation to, diverse stress stimuli1.