Soumya Kundu

1 week ago | biorxiv.org | Chad S. Weldy |Soumya Kundu |Joao Monteiro |Wenduo Gu

AbstractVascular sites have distinct susceptibility to atherosclerosis and aneurysm, yet the biological underpinning of vascular site-specific disease risk is largely unknown. Vascular tissues have different developmental origins that may influence global chromatin accessibility, and understanding differential chromatin accessibility, gene expression profiles, and gene regulatory networks (GRN) on single cell resolution may give key insight into vascular site-specific disease risk.

2 months ago | biorxiv.org | Andrew R. Marderstein |Soumya Kundu |Evin M. Padhi |Salil Deshpande

AbstractWhole genome sequencing has identified over a billion non-coding variants in humans, while GWAS has revealed the non-coding genome as a significant contributor to disease. However, prioritizing causal common and rare non-coding variants in human disease, and understanding how selective pressures have shaped the non-coding genome, remains a significant challenge.