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Nov 29, 2024 | 
science.org | Young-Cheul Shin |Yang Wu |Chaojiao Sun |Lifang Sun
AbstractOwing to superior strength-ductility combination and great potential for applications in extreme conditions, high-entropy alloys (HEAs) with the face-centered cubic (FCC) structure have drawn enormous attention. However, the FCC structure limits yield strength and makes the alloys unable to meet ever-increasing demands for exploring the universe.
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Nov 29, 2024 | 
science.org | Young-Cheul Shin |Yang Wu |Chaojiao Sun |Khachatur G. Nazaryan
AbstractWe uncover a superconducting state with partial spin polarization induced by a magnetic field. This state, which we call “magnonic superconductor,” lacks a conventional pairing order parameter but is characterized instead by a composite order parameter that represents the binding of electron pairs and magnons.
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Nov 29, 2024 | 
science.org | Young-Cheul Shin |Yang Wu |Chaojiao Sun |Shengshun Duan
AbstractHybrid organic-inorganic molecular ferroelectrics have emerged as promising materials for multifunctional piezoelectric devices. However, they present challenges in practical applications because of their inherent brittleness and poor ductility. Herein, we present a flexible mechano-optical dual-responsive molecular ferroelectric composite by incorporating trimethylchloromethyl ammonium (TMCM)–MnCl3 into styrene ethylene butylene styrene (SEBS) matrix.
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Nov 29, 2024 | 
science.org | Young-Cheul Shin |Yang Wu |Chaojiao Sun |Xingguang Li
AbstractThe conventional molecular immunogenic cell death (ICD) inducers suffer from poor biocompatibility and unsatisfactory efficacy. Here, a biocompatible nanosized covalent organic framework (nCOF)–based pyroelectric catalyst (denoted as TPAD-COF NPs) is designed for pyroelectric catalysis-activated in situ immunotherapy.
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Nov 29, 2024 | 
science.org | Young-Cheul Shin |Yang Wu |Chaojiao Sun |Kun Shi
AbstractEngineering nonribosomal peptide synthetases (NRPSs) has been a “holy grail” in synthetic biology due to their modular nature and limited understanding of catalytic mechanisms. Here, we reported a computational redesign of the “gate-keeper” adenylation domain of the model NRPS-like enzyme carboxylic acid reductases (CARs) by using approximate mechanism-based geometric criteria and the Rosetta energy score.
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Nov 29, 2024 | 
science.org | Young-Cheul Shin |Yang Wu |Chaojiao Sun |Shixiong Chen
AbstractMicroplastic remediation in aquatic bodies is essential for the entire ecosystem, but is challenging to achieve with a universal and efficient strategy. Here, we developed a sustainable and environmentally adaptable adsorbent through supramolecular self-assembly of chitin and cellulose. This biomass fibrous framework (Ct-Cel) showcases an excellent adsorption performance for polystyrene, polymethyl methacrylate, polypropylene, and polyethylene terephthalate.
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Nov 29, 2024 | 
science.org | Young-Cheul Shin |Yang Wu |Chaojiao Sun |Nicolas Pereira
AbstractSevere asthma induces substantial mortality and chronic disability due to intractable airway obstruction, which may become resistant to currently available therapies including corticosteroids and β-adrenergic agonist bronchodilators. A key effector of these changes is exaggerated airway smooth muscle (ASM) cell contraction to spasmogens. No drugs in clinical use effectively prevent ASM hyperresponsiveness in asthma across all severities.
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Nov 29, 2024 | 
science.org | Young-Cheul Shin |Yang Wu |Chaojiao Sun |Zhichao Xu
AbstractBerberine is an effective antimicrobial and antidiabetic alkaloid, primarily extracted from divergent botanical lineages, specifically Coptis (Ranunculales, early-diverging eudicot) and Phellodendron (Sapindales, core eudicot). In comparison with its known pathway in Coptis species, its biosynthesis in Phellodendron species remains elusive.
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Nov 29, 2024 | 
science.org | Young-Cheul Shin |Yang Wu |Chaojiao Sun |Christopher Gisriel
AbstractPhotosystem I (PS I) is a light-driven oxidoreductase responsible for converting photons into chemical bond energy. Its application for renewable energy was revolutionized by the creation of the MenB deletion (ΔmenB) variant in the cyanobacterium Synechocystis sp. PCC 6803, in which phylloquinone is replaced by plastoquinone-9 with a low binding affinity.
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Nov 29, 2024 | 
science.org | Young-Cheul Shin |Yang Wu |Chaojiao Sun |Arlene Martinez-Rivera
AbstractConverging findings have established that the endocannabinoid (eCB) system serves as a possible target for the development of new treatments as a complement to opioid-based treatments.
