Zhichao Xu

3 weeks ago | mdpi.com | Liuxi Li |Chao Deng |Yuan Chen |Zhichao Xu

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2 months ago | biorxiv.org | Zhiyu Kang |Li Chen |Peng Wei |Zhichao Xu

AbstractMediation analysis helps uncover how exposures impact outcomes through intermediate variables. Traditional mean-based total mediation effect measures can suffer from the cancellation of opposite component-wise effects and existing methods often lack the power to capture weak effects in high-dimensional mediators. Additionally, most existing work has focused on continuous outcomes, with limited attention to binary outcomes, particularly in case-control studies.

Nov 29, 2024 | science.org | Young-Cheul Shin |Yang Wu |Chaojiao Sun |Zhichao Xu

AbstractBerberine is an effective antimicrobial and antidiabetic alkaloid, primarily extracted from divergent botanical lineages, specifically Coptis (Ranunculales, early-diverging eudicot) and Phellodendron (Sapindales, core eudicot). In comparison with its known pathway in Coptis species, its biosynthesis in Phellodendron species remains elusive.

Apr 30, 2024 | biorxiv.org | Zhichao Xu |Peng Wei

AbstractMeta-analysis is used to aggregate the effects of interest across multiple studies, while its methodology is largely underexplored in mediation analysis, particularly in estimating the total mediation effect of high-dimensional omics mediators.

Aug 4, 2023 | nature.com | Shi Qiu |Zhichao Xu |Junfeng Chen

AbstractThe genus Salvia L. (Lamiaceae) comprises myriad distinct medicinal herbs, with terpenoids as one of their major active chemical groups. Abietane-type diterpenoids (ATDs), such as tanshinones and carnosic acids, are specific to Salvia and exhibit taxonomic chemical diversity among lineages.