Charles Schleifer

Apr 5, 2024 | biorxiv.org | Charles Schleifer |Sarah Chang |Carolyn Amir |Kathleen O'Hora

AbstractBackground: 22q11.2 Deletion Syndrome (22qDel) is a copy number variant (CNV) associated with psychosis and other neurodevelopmental disorders. Adolescents at clinical high risk for psychosis (CHR) have subthreshold psychosis symptoms without known genetic risk factors. Whether common neural substrates underlie these distinct high-risk populations is unknown. We compared functional brain measures in 22qDel and CHR cohorts and mapped results to biological pathways.

Mar 1, 2024 | nature.com | Charles Schleifer

AbstractThe 22q11.2 locus contains genes critical for brain development. Reciprocal Copy Number Variations (CNVs) at this locus impact risk for neurodevelopmental and psychiatric disorders. Both 22q11.2 deletions (22qDel) and duplications (22qDup) are associated with autism, but 22qDel uniquely elevates schizophrenia risk. Understanding brain phenotypes associated with these highly penetrant CNVs can provide insights into genetic pathways underlying neuropsychiatric disorders.

Feb 21, 2024 | biologicalpsychiatryjournal.com | Charles Schleifer |Sarah Chang |Carolyn Amir |Kathleen O'Hora

22q11.2 Deletion Syndrome (22qDel) is a copy number variant (CNV) associated with schizophrenia and other neurodevelopmental disorders. Studying this population provides a framework for linking genes to neuropsychiatric phenotypes. Adolescents at clinical high risk for psychosis (CHR) have sub-threshold psychosis symptoms without a known genetic risk factor.

Jan 10, 2024 | biologicalpsychiatryjournal.com | Charles Schleifer

Accurate psychiatric risk assessment requires biomarkers that are both stable and adaptable to development. Functional network connectivity (FNC), which steadily reconfigures over time, potentially contains abundant information to assess psychiatric risks. However, the absence of suitable analytical methodologies has constrained this area of investigation.