Kathleen O'Hora

Apr 5, 2024 | biorxiv.org | Charles Schleifer |Sarah Chang |Carolyn Amir |Kathleen O'Hora

AbstractBackground: 22q11.2 Deletion Syndrome (22qDel) is a copy number variant (CNV) associated with psychosis and other neurodevelopmental disorders. Adolescents at clinical high risk for psychosis (CHR) have subthreshold psychosis symptoms without known genetic risk factors. Whether common neural substrates underlie these distinct high-risk populations is unknown. We compared functional brain measures in 22qDel and CHR cohorts and mapped results to biological pathways.

Feb 21, 2024 | biologicalpsychiatryjournal.com | Charles Schleifer |Sarah Chang |Carolyn Amir |Kathleen O'Hora

22q11.2 Deletion Syndrome (22qDel) is a copy number variant (CNV) associated with schizophrenia and other neurodevelopmental disorders. Studying this population provides a framework for linking genes to neuropsychiatric phenotypes. Adolescents at clinical high risk for psychosis (CHR) have sub-threshold psychosis symptoms without a known genetic risk factor.