Sarah Chang

Nov 16, 2024 | hercampus.com | Sarah Chang

With midterms ending and finals fast approaching, I have compiled a list of my favorite cafes that serve my personal favorite drink—matcha. It’s important to reward yourself when studying for big exams, and for me, the best reward was visiting different cafes around Boston. TatteTatte is the city’s tried and true cafe. Visiting Boston, you have to try this cafe at least once for their brunch or dessert options.

Oct 17, 2024 | pubs.rsc.org | Sarah Chang |Lilyanna Armstrong |Nia Clements

Molecular recognition of peptides and proteins by cucurbit[n]urils: systems and applications The development of methodology for attaching ligand binding sites to proteins of interest has accelerated biomedical science. Such protein tags have widespread applications as well as properties that significantly limit their utility.

Jun 17, 2024 | nature.com | Leonardo Tozzi |Xue Zhang |Adam R. Pines |Emily Zhai |Sarah Chang |Laura Hack | +11 more

There is an urgent need to derive quantitative measures based on coherent neurobiological dysfunctions or ‘biotypes’ to enable stratification of patients with depression and anxiety. We used task-free and task-evoked data from a standardized functional magnetic resonance imaging protocol conducted across multiple studies in patients with depression and anxiety when treatment free (n = 801) and after randomization to pharmacotherapy or behavioral therapy (n = 250). From these patients, we derived personalized and interpretable scores of brain circuit dysfunction grounded in a theoretical taxonomy. Participants were subdivided into six biotypes defined by distinct profiles of intrinsic task-free functional connectivity within the default mode, salience and frontoparietal attention circuits, and of activation and connectivity within frontal and subcortical regions elicited by emotional and cognitive tasks. The six biotypes showed consistency with our theoretical taxonomy and were distinguished by symptoms, behavioral performance on general and emotional cognitive computerized tests, and response to pharmacotherapy as well as behavioral therapy. Our results provide a new, theory-driven, clinically validated and interpretable quantitative method to parse the biological heterogeneity of depression and anxiety. Thus, they represent a promising approach to advance precision clinical care in psychiatry. Personalized brain circuit measures quantified using a new imaging technology in 801 patients with depression and anxiety identify six biotypes with unique symptoms, behaviors and responses to different types of treatment.

Jun 11, 2024 | ejog.org | Rachael Fox |Sarah Chang |Lauren Hicks |Samantha S Mooney

Shafrir A.L. Farland L.V. Shah D.K. Harris H.R. Kvaskoff M. Zondervan K. et al. Risk for and consequences of endometriosis: A critical epidemiologic review. Best Pract Res Clin Obstet Gynaecol [Internet]. 2018; 51 (): 1-15Swift B. Taneri B. Becker C.M. Basarir H. Naci H. Missmer S.A. et al. Prevalence, diagnostic delay and economic burden of endometriosis and its impact on quality of life: results from an Eastern Mediterranean population. Eur J Public Health [Internet].

Apr 29, 2024 | biologicalpsychiatryjournal.com | Sarah Chang |Dylan Hughes |Jinhan Zhu |Sullivan Salone

Across domains of cognitive deficits in schizophrenia (SCZ), attention is among the most significantly impaired. Deficits are present long before onset of overt illness and are also observed in unaffected first-degree relatives. Collectively, findings suggest that attention impairments and accompanying alterations in neurodevelopment may reflect genetic liability to SCZ.