Chenchu Lin

Aug 30, 2024 | digitalcommons.library.tmc.edu | Sean O'Byrne |Yi Liang |Thomas L. Pulliam |Chenchu Lin

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Sep 5, 2023 | biorxiv.org | Chenchu Lin |Xingdi Ma |Lori Wilson |Nazanin Esmaeili Anvar

AbstractGenetic interactions mediate the emergence of phenotype from genotype, but initial technologies for combinatorial genetic perturbation in mammalian cells suffer from inefficiency and are challenging to scale. Recent focus on paralog synthetic lethality in cancer cells offers an opportunity to evaluate different approaches and improve on the state of the art.