Xingdi Ma

Aug 9, 2024 | digitalcommons.library.tmc.edu | Xingdi Ma

The emergence of high-throughput sequencing technologies and the development of targeted cancer therapies have significantly advanced our understanding of cancer genomics and prolonged patient survival. Despite these advances, durable response remains difficult to achieve in the clinic. The concept of synthetic lethality has gained traction as a promising opportunity to discover novel cancer-specific vulnerabilities and therapeutic targets.

Sep 5, 2023 | biorxiv.org | Chenchu Lin |Xingdi Ma |Lori Wilson |Nazanin Esmaeili Anvar

AbstractGenetic interactions mediate the emergence of phenotype from genotype, but initial technologies for combinatorial genetic perturbation in mammalian cells suffer from inefficiency and are challenging to scale. Recent focus on paralog synthetic lethality in cancer cells offers an opportunity to evaluate different approaches and improve on the state of the art.