Chenhao Tong

3 weeks ago | biorxiv.org | Tao Lin |Chenjun Huang |Chenhao Tong |Wentao Xu

AbstractPhysiologically, hepatocytes perform an estimated 500 essential liver functions to ensure systemic homeostasis. The mechanisms how hepatocytes maintain these numerous crucial functions in response to physiological and pathophysiological challenges are largely unknown. In this study, we found that vital liver function genes (e.g., HNF4A, ALB, coagulation factors, and SLC2A2) in hepatocytes possess super-enhancers.

3 weeks ago | biorxiv.org | Chenhao Tong |Tao Lin |Han Wang |Hui Liu

AbstractLiver progenitor cells (LPCs) are the smallest cholangiocytes that perform hepatocyte functions to rescue the lives of patients suffering from acute liver failure (ALF) caused by massive hepatic necrosis (MHN). To date, it remains largely unknown how LPCs remain quiescent and become activated following MHN. This study elucidates the essential role of TGF-β in regulating LPC quiescence and activation.