Chenjun Huang

3 weeks ago | biorxiv.org | Tao Lin |Chenjun Huang |Chenhao Tong |Wentao Xu

AbstractPhysiologically, hepatocytes perform an estimated 500 essential liver functions to ensure systemic homeostasis. The mechanisms how hepatocytes maintain these numerous crucial functions in response to physiological and pathophysiological challenges are largely unknown. In this study, we found that vital liver function genes (e.g., HNF4A, ALB, coagulation factors, and SLC2A2) in hepatocytes possess super-enhancers.

Dec 8, 2023 | onlinelibrary.wiley.com | Xiao Xiao |Lin Zhou |Fuxiang Chen |Chenjun Huang

1 INTRODUCTION Primary liver cancer (PLC) is the sixth most common cancer worldwide in terms of the number of cases of 906,000 with an age-standardized incidence rate of 9.5/100,000, which mainly includes hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC) and mixed HCC-cholangiocarcinoma (HCC-ICC), with incidences of 93.0%, 4.3% and 1.6%, respectively.1-3 PLC is the second cause of tumor-related deaths in China, with a mortality rate of 24.33 per 10,000 (males: 35.25 and...