Chiara Caraccio

Oct 30, 2024 | nature.com | Johanna Klughammer |Daniel L. Abravanel |Timothy R. Blosser |Yury Goltsev |Chiara Caraccio |Nicole Cullen | +7 more

AbstractAlthough metastatic disease is the leading cause of cancer-related deaths, its tumor microenvironment remains poorly characterized due to technical and biospecimen limitations. In this study, we assembled a multi-modal spatial and cellular map of 67 tumor biopsies from 60 patients with metastatic breast cancer across diverse clinicopathological features and nine anatomic sites with detailed clinical annotations.

Jul 19, 2023 | nature.com | John Hickey |Winston R. Becker |Chenchen Zhu |Derek Chen |Daniel Cotter |Annika K Weimer | +10 more

AbstractThe intestine is a complex organ that promotes digestion, extracts nutrients, participates in immune surveillance, maintains critical symbiotic relationships with microbiota and affects overall health1. The intesting has a length of over nine metres, along which there are differences in structure and function2. The localization of individual cell types, cell type development trajectories and detailed cell transcriptional programs probably drive these differences in function.