Chongzhao You

3 days ago | nature.com | Chongzhao You |Shimeng Guo |Tianwei Zhang |Xinheng He |Youwei Xu |Yi Jiang | +1 more

AbstractMaintaining pH homeostasis is critical for cellular function across all living organisms. Proton-sensing G protein-coupled receptors (GPCRs), particularly GPR4, play a pivotal role in cellular responses to pH changes. Yet, the molecular mechanisms underlying their proton sensing and activation remain incompletely understood. Here we present high-resolution cryo-electron microscopy structures of GPR4 in complex with G proteins under physiological and acidic pH conditions.