Xinheng He

3 days ago | nature.com | Chongzhao You |Shimeng Guo |Tianwei Zhang |Xinheng He |Youwei Xu |Yi Jiang | +1 more

AbstractMaintaining pH homeostasis is critical for cellular function across all living organisms. Proton-sensing G protein-coupled receptors (GPCRs), particularly GPR4, play a pivotal role in cellular responses to pH changes. Yet, the molecular mechanisms underlying their proton sensing and activation remain incompletely understood. Here we present high-resolution cryo-electron microscopy structures of GPR4 in complex with G proteins under physiological and acidic pH conditions.

Jun 3, 2024 | nature.com | Xinheng He

Dear Editor,Succinic acid, once considered merely a tricarboxylic acid cycle intermediate,1 has been recognized for its significant role in influencing mitochondrial reactive oxygen species homeostasis.2 This is largely mediated through the G protein-coupled succinate receptor (SUCR1, also known as GPR91), which has emerged as a vital link connecting metabolic status to a myriad of physiological and pathological processes.