Chris Finan

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Articles

Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification - Nature Genetics

Sep 28, 2023 | nature.com | Maryam Kavousi |Haojie Lu |Chani J. Hodonsky |Joris Deelen |Xiuqing Guo |Leo-Pekka Lyytikäinen | +31 more

AbstractCoronary artery calcification (CAC), a measure of subclinical atherosclerosis, predicts future symptomatic coronary artery disease (CAD). Identifying genetic risk factors for CAC may point to new therapeutic avenues for prevention. Currently, there are only four known risk loci for CAC identified from genome-wide association studies (GWAS) in the general population.
Genome-wide association meta-analysis of spontaneous coronary artery dissection identifies risk variants and genes related to artery integrity and tissue-mediated coagulation | Nature Genetics

May 29, 2023 | nature.com | David Adlam |Takiy-Eddine Berrandou |Adrien Georges |Christopher Nelson |Chris Finan |Siiri E. Iismaa | +21 more

AbstractSpontaneous coronary artery dissection (SCAD) is an understudied cause of myocardial infarction primarily affecting women. It is not known to what extent SCAD is genetically distinct from other cardiovascular diseases, including atherosclerotic coronary artery disease (CAD). Here we present a genome-wide association meta-analysis (1,917 cases and 9,292 controls) identifying 16 risk loci for SCAD.

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