Xiuqing Guo

May 6, 2024 | nature.com | Yash Pershad |Adrienne M. Stilp |Braxton D. Mitchell |Joshua Lewis |Nathalie Chami |Zhe Wang | +21 more

AbstractClonal hematopoiesis (CH) is characterized by the acquisition of a somatic mutation in a hematopoietic stem cell that results in a clonal expansion. These driver mutations can be single nucleotide variants in cancer driver genes or larger structural rearrangements called mosaic chromosomal alterations (mCAs). The factors that influence the variations in mCA fitness and ultimately result in different clonal expansion rates are not well understood.

Dec 28, 2023 | jamanetwork.com | Philip Greenland |Donald M. Lloyd-Jones |Sadiya Khan |Xiuqing Guo

Heart artery blockages start with cholesterol deposits, or plaques, that build up in the heart artery walls. Over time, these plaques can become hardened, or calcified. The calcium in plaques can be measured by a coronary computed tomographic scan. The scan takes 10 to 15 minutes and does not require any intravenous contrast or dye.

Oct 30, 2023 | nature.com | Yasminka A. Jakubek |Adrienne M. Stilp |Justin Wong |Zuhal Özcan |Kathleen C. Barnes |Joshua C. Bis | +22 more

AbstractMegabase-scale mosaic chromosomal alterations (mCAs) in blood are prognostic markers for a host of human diseases. Here, to gain a better understanding of mCA rates in genetically diverse populations, we analyzed whole-genome sequencing data from 67,390 individuals from the National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine program.

Sep 28, 2023 | nature.com | Maryam Kavousi |Haojie Lu |Chani J. Hodonsky |Joris Deelen |Xiuqing Guo |Leo-Pekka Lyytikäinen | +31 more

AbstractCoronary artery calcification (CAC), a measure of subclinical atherosclerosis, predicts future symptomatic coronary artery disease (CAD). Identifying genetic risk factors for CAC may point to new therapeutic avenues for prevention. Currently, there are only four known risk loci for CAC identified from genome-wide association studies (GWAS) in the general population.

Jun 8, 2023 | nature.com | Alice Williamson |Anne Jackson |Mette Andersen |Thomas Buchanan |Lee-Ming Chuang |Ren-Hua Chung | +43 more

Author notesThese authors jointly supervised this work: Karen L. Mohlke, Eleanor Wheeler, Stephen O’Rahilly, Daniel J. Fazakerley,Claudia Langenberg. Authors and AffiliationsMRC Epidemiology Unit Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UKAlice Williamson, Jian’an Luan, Nicholas J.