Adrien Georges

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Articles

Integrative gene regulatory network analysis discloses key driver genes of fibromuscular dysplasia - Nature Cardiovascular Research

Sep 12, 2024 | nature.com | Sizhao Lu |Yang Xu |Shouneng Peng |Adrien Georges |Aya Nomura-Kitabayashi |Robert Wiener | +5 more

AbstractFibromuscular dysplasia (FMD) is a poorly understood disease affecting 3–5% of adult females. The pathobiology of FMD involves arterial lesions of stenosis, dissection, tortuosity, dilation and aneurysm, which can lead to hypertension, stroke, myocardial infarction and even death. Currently, there are no animal models for FMD and few insights as to its pathobiology.
Genome-wide association meta-analysis of spontaneous coronary artery dissection identifies risk variants and genes related to artery integrity and tissue-mediated coagulation | Nature Genetics

May 29, 2023 | nature.com | David Adlam |Takiy-Eddine Berrandou |Adrien Georges |Christopher Nelson |Chris Finan |Siiri E. Iismaa | +21 more

AbstractSpontaneous coronary artery dissection (SCAD) is an understudied cause of myocardial infarction primarily affecting women. It is not known to what extent SCAD is genetically distinct from other cardiovascular diseases, including atherosclerotic coronary artery disease (CAD). Here we present a genome-wide association meta-analysis (1,917 cases and 9,292 controls) identifying 16 risk loci for SCAD.

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