Chris J. Norbury

Jul 25, 2024 | nature.com | Gangshun Yi |Mingda Ye |Loïc Carrique |Afaf H. El-Sagheer |Tom Brown |Chris J. Norbury | +1 more

AbstractTumor-suppressor let-7 pre-microRNAs (miRNAs) are regulated by terminal uridylyltransferases TUT7 and TUT4 that either promote let-7 maturation by adding a single uridine nucleotide to the pre-miRNA 3′ end or mark them for degradation by the addition of multiple uridines. Oligo-uridylation is increased in cells by enhanced TUT7/4 expression and especially by the RNA-binding pluripotency factor LIN28A.