Loïc Carrique

Dec 9, 2024 | journals.plos.org | Jeremy Keown |Loïc Carrique |Benjamin E. Nilsson-Payant |PLOS Pathogens

Loading metrics Open Access Peer-reviewedResearch Article ? This is an uncorrected proof. Citation: Keown JR, Carrique L, Nilsson-Payant BE, Fodor E, Grimes JM (2024) Structural characterization of the full-length Hantaan virus polymerase. PLoS Pathog 20(12): e1012781.

Jul 25, 2024 | nature.com | Gangshun Yi |Mingda Ye |Loïc Carrique |Afaf H. El-Sagheer |Tom Brown |Chris J. Norbury | +1 more

AbstractTumor-suppressor let-7 pre-microRNAs (miRNAs) are regulated by terminal uridylyltransferases TUT7 and TUT4 that either promote let-7 maturation by adding a single uridine nucleotide to the pre-miRNA 3′ end or mark them for degradation by the addition of multiple uridines. Oligo-uridylation is increased in cells by enhanced TUT7/4 expression and especially by the RNA-binding pluripotency factor LIN28A.

May 14, 2024 | nature.com | Ecco Staller |Loïc Carrique |Haitian Fan |Jeremy Keown |Carol M. Sheppard |Wendy Barclay | +1 more

AbstractAvian influenza A viruses (IAVs) pose a public health threat, as they are capable of triggering pandemics by crossing species barriers. Replication of avian IAVs in mammalian cells is hindered by species-specific variation in acidic nuclear phosphoprotein 32 (ANP32) proteins, which are essential for viral RNA genome replication. Adaptive mutations enable the IAV RNA polymerase (FluPolA) to surmount this barrier.

Jun 9, 2023 | biorxiv.org | Jeremy Keown |Loïc Carrique |Benjamin E. Nilsson-Payant |Ervin Fodor

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