Tom Brown

Jul 25, 2024 | nature.com | Gangshun Yi |Mingda Ye |Loïc Carrique |Afaf H. El-Sagheer |Tom Brown |Chris J. Norbury | +1 more

AbstractTumor-suppressor let-7 pre-microRNAs (miRNAs) are regulated by terminal uridylyltransferases TUT7 and TUT4 that either promote let-7 maturation by adding a single uridine nucleotide to the pre-miRNA 3′ end or mark them for degradation by the addition of multiple uridines. Oligo-uridylation is increased in cells by enhanced TUT7/4 expression and especially by the RNA-binding pluripotency factor LIN28A.

Mar 14, 2024 | northwestgeorgianews.com | Tom Brown

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Jun 23, 2023 | nature.com | Marta Victoria |Tom Brown |Elisabeth Zeyen

Model descriptionWe use the open-source European sector coupled model PyPSA-Eur-Sec30, which minimises total system costs while optimising generation, storage and distribution capacity and dispatch. It covers energy and feedstock demand in the sectors electricity, heating, transport and industry. The model has already been presented in detail in various publications33,47,48,49, so in the following only the newly implemented features for this study are presented.