Christian M. Metallo

2 months ago | nature.com | Trever T. Greene |Carolina Chiale |Yu Fujita |Thekla Cordes |Christian M. Metallo |David Scott

AbstractType I Interferons (IFN-I) are central to host protection against viral infections, with plasmacytoid dendritic cells (pDC) being the most significant source, yet pDCs lose their IFN-I production capacity following an initial burst of IFN-I, resulting in susceptibility to secondary infections. The underlying mechanisms of these dynamics are not well understood. Here we find that viral infection reduces the capacity of pDCs to engage both oxidative and glycolytic metabolism.

Jan 7, 2025 | cell.com | Joyce Liu |Ramya S. Kuna |Laura V Pinheiro |Phuong Nguyen |Phương Nguyên |Jaclyn E. Welles | +17 more

KeywordsACLYbempedoic acidlipid metabolismmetabolic dysfunction-associated steatotic liver diseaseACSS2PPARαIntroductionAffecting about 1 in 4 individuals globally,1,2 metabolic dysfunction-associated steatotic liver disease (MASLD) encapsulates a spectrum of pathologies fundamentally characterized by steatosis, or excess lipid accumulation, in hepatocytes.

Jul 25, 2024 | cell.com | Heather Christofk |Christian M. Metallo |Guanghui Liu |Joshua D. Rabinowitz

Recent advancements in technology, especially the emergence of single-cell technologies, genomic sequencing, metabolomics, and artificial intelligence, have enabled us to understand the distinct metabolic changes in different cell types, tissues, genders, disease states, ages, and populations. Six scientists whose work intersects with metabolism in various capacities tell us about their vision for human metabolic heterogeneity.