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Jan 24, 2025 | 
nature.com | Kyle Coleman |Jeong Hwan Park |Hanying Yan |Isabel Barnfather |Joshua D. Rabinowitz |Yanxiang Deng | +5 more
Correction to: Nature Methods https://doi.org/10.1038/s41592-024-02574-2, published online 15 January 2025. In the version of the article initially published, the Data availability and Code availability sections were inadvertently omitted. These sections have now been included in the HTML and PDF versions of the article. About this articleColeman, K., Schroeder, A., Loth, M. et al. Author Correction: Resolving tissue complexity by multimodal spatial omics modeling with MISO. Nat Methods (2025).
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Jan 15, 2025 | 
nature.com | Kyle Coleman |Jeong Hwan Park |Hanying Yan |Joshua D. Rabinowitz |Yanxiang Deng |Edward Lee | +5 more
AbstractSpatial molecular profiling has provided biomedical researchers valuable opportunities to better understand the relationship between cellular localization and tissue function. Effectively modeling multimodal spatial omics data is crucial for understanding tissue complexity and underlying biology.
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Oct 23, 2024 | 
jdsupra.com | Joshua D. Rabinowitz
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Sep 17, 2024 | 
nature.com | Khanh V. Doan |Won Dong Lee |Sarmistha Mukherjee |Gabriel K. Adzika |Ryan B. Gaspar |Corey Holman | +3 more
AbstractNicotinamide adenine dinucleotide (NAD+) is an essential co-factor in metabolic reactions and co-substrate for signaling enzymes. Failing human hearts display decreased expression of the major NAD+ biosynthetic enzyme nicotinamide phosphoribosyltransferase (Nampt) and lower NAD+ levels, and supplementation with NAD+ precursors is protective in preclinical models.
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Jul 25, 2024 | 00708-6&sz=64)
cell.com | Heather Christofk |Christian M. Metallo |Guanghui Liu |Joshua D. Rabinowitz
Recent advancements in technology, especially the emergence of single-cell technologies, genomic sequencing, metabolomics, and artificial intelligence, have enabled us to understand the distinct metabolic changes in different cell types, tissues, genders, disease states, ages, and populations. Six scientists whose work intersects with metabolism in various capacities tell us about their vision for human metabolic heterogeneity.
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Jul 11, 2024 | 
nature.com | Samuel Wang |Eduardo Lopes |Jonathan M. Ghergurovich |Xiaoyang Su |Joshua D. Rabinowitz |Eileen White
AbstractCancer cells depend on nicotinamide adenine dinucleotide phosphate (NADPH) to combat oxidative stress and support reductive biosynthesis. One major NADPH production route is the oxidative pentose phosphate pathway (committed step: glucose-6-phosphate dehydrogenase, G6PD). Alternatives exist and can compensate in some tumors.
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Jul 2, 2024 | 
jdsupra.com | Jessica Mullinix |Joshua D. Rabinowitz
Effective July 1, 2024, California residential landlords will generally only be able to charge security deposits equal to one month’s rent with some exceptions for smaller landlords. This is pursuant to Assembly Bill 12 approved in 2023 by California Gov.
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Apr 8, 2024 | 
nature.com | Joshua D. Rabinowitz |Soodabeh Ghaffari
AbstractPseudomonas aeruginosa is a leading cause of hospital-acquired infections for which the development of antibiotics is urgently needed. Unlike most enteric bacteria, P. aeruginosa lacks enzymes required to scavenge exogenous thymine. An appealing strategy to selectively target P. aeruginosa is to disrupt thymidine synthesis while providing exogenous thymine. However, known antibiotics that perturb thymidine synthesis are largely inactive against P. aeruginosa.
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Feb 7, 2024 | 
nature.com | Somesh Mishra |Sarang S. Bhagwat |Joshua D. Rabinowitz |Jeremy S. Guest |vijay Singh
Correction to: Nature Communications https://doi.org/10.1038/s41467-023-41616-9, published online 3 October 2023The original version of this Article contained an error in Fig. 2, in which the legends for “titer” and “productivity” were swapped. This has been corrected in both the PDF and HTML versions of the Article.
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Oct 31, 2023 | 
nature.com | Brandon Faubert |Joshua D. Rabinowitz
AbstractMetabolic reprogramming is central to malignant transformation and cancer cell growth. How tumours use nutrients and the relative rates of reprogrammed pathways are areas of intense investigation. Tumour metabolism is determined by a complex and incompletely defined combination of factors intrinsic and extrinsic to cancer cells. This complexity increases the value of assessing cancer metabolism in disease-relevant microenvironments, including in patients with cancer.
