Christian Macdonald

May 3, 2024 | cell.com | Christian Macdonald |Darko Mitrovic |Xujia Zhou

Highlights•Deep mutational scan of OCT1 reveals the determinants of biogenesis and substrate uptake•Discovery of a conserved motif, the stability helix, essential to SLC22 biogenesis•AI structure prediction and mutational data for accurate structure-function modeling•Integrating genomic-health records reveals variants effect on human physiologySummaryMutations in transporters can impact an individual’s response to drugs and cause many diseases.

Feb 22, 2024 | yahoo.com | Christian Macdonald |Anastasia Barbieri

"Hearst Magazines and Yahoo may earn commission or revenue on some items through these links."Inspired by the lives of famed female aviators and explorers, our heroine, the Italian model Paola Manes, sets out for the idyllic setting that is Mexico’s Maya Forest. Of course, she’s packed an adventure-ready wardrobe, from intricate crochets to sturdy workwear. Beauty Tip: For long-lasting moisture, try SISLEY PARIS All Day All Year Essential Anti-Aging Protection ($500).

Jun 7, 2023 | biorxiv.org | Christian Macdonald |Xujia Zhou |Darko Mitrovic

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