Xujia Zhou

Jul 27, 2024 | biorxiv.org | Xujia Zhou |Mina Azimi |Niklas Handin |Andrew Riselli

AbstractThe Blood-Brain Barrier (BBB) is a crucial, selective barrier that regulates the entry of molecules including nutrients, environmental toxins, and therapeutic medications into the brain. This function relies heavily on brain endothelial cell proteins, particularly transporters and tight junction proteins. The BBB continues to develop postnatally, adapting its selective barrier function across different developmental phases, and alters with aging and disease.

May 3, 2024 | cell.com | Christian Macdonald |Darko Mitrovic |Xujia Zhou

Highlights•Deep mutational scan of OCT1 reveals the determinants of biogenesis and substrate uptake•Discovery of a conserved motif, the stability helix, essential to SLC22 biogenesis•AI structure prediction and mutational data for accurate structure-function modeling•Integrating genomic-health records reveals variants effect on human physiologySummaryMutations in transporters can impact an individual’s response to drugs and cause many diseases.

Feb 26, 2024 | cell.com | Chenyu Wang |Kimberly D Derderian |Elizabeth Hamada |Xujia Zhou |Andrew Nelson |Henry Kyoung | +3 more

Jun 7, 2023 | biorxiv.org | Christian Macdonald |Xujia Zhou |Darko Mitrovic

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Jun 7, 2023 | biorxiv.org | Chenyu Wang |Kimberly D Derderian |Elizabeth Hamada |Xujia Zhou

Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website.