Darko Mitrovic

May 3, 2024 | cell.com | Christian Macdonald |Darko Mitrovic |Xujia Zhou

Highlights•Deep mutational scan of OCT1 reveals the determinants of biogenesis and substrate uptake•Discovery of a conserved motif, the stability helix, essential to SLC22 biogenesis•AI structure prediction and mutational data for accurate structure-function modeling•Integrating genomic-health records reveals variants effect on human physiologySummaryMutations in transporters can impact an individual’s response to drugs and cause many diseases.

Jun 7, 2023 | biorxiv.org | Christian Macdonald |Xujia Zhou |Darko Mitrovic

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