Christian Wright

4 weeks ago | digitalcommons.library.tmc.edu | Madison Kelly |Karan Sharma |Christian Wright |Xin Yi

α2δ1 subunit, mechanotransduction, voltage-sensitive calcium channel, bone formation, loading 10.1093/jbmrpl/ziad008 Post-print Kelly, Madison M; Sharma, Karan; Wright, Christian S; Yi, Xin; Reyes Fernandez, Perla C; Gegg, Aaron T; Gorrell, Taylor A; Noonan, Megan L; Baghdady, Ahmed; Sieger, Jacob A; Dolphin, Annette C; Warden, Stuart J; Deosthale, Padmini; Plotkin, Lilian I; Sankar, Uma; Hum, Julia M; Robling, Alexander G; Farach-Carson, Mary C; and Thompson, William R, "Loss of the...

Aug 29, 2024 | digitalcommons.library.tmc.edu | Madison Kelly |Karan Sharma |Christian Wright |Xin Yi

AbstractVoltage-sensitive calcium channels (VSCCs) influence bone structure and function, including anabolic responses to mechanical loading. While the pore-forming (α1) subunit of VSCCs allows Ca2+ influx, auxiliary subunits regulate the biophysical properties of the pore. The α2δ1 subunit influences gating kinetics of the α1 pore and enables mechanically induced signaling in osteocytes; however, the skeletal function of α2δ1 in vivo remains unknown.