Christina S. Boncyk

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INhaled Sedation versus Propofol in REspiratory failure in the Intensive Care Unit (INSPiRE-ICU1): protocol for a randomised, controlled trial

Oct 26, 2024 | bmjopen.bmj.com | Christina S. Boncyk |John Devlin |Hina Faisal |Timothy D. Girard

Methods and analysisTrial designINSPiRE-ICU1 is a phase 3, multicentre, randomised, controlled, open-label, assessor-blinded trial evaluating the efficacy and safety of inhaled isoflurane delivered via the Sedaconda ACD-S compared with intravenous propofol for the sedation of mechanically ventilated adults ICU patients. INSPiRE-ICU1 is the first of two, methodologically identical, parallel phase 3 trials (INSPiRE-ICU1 and INSPiRE-ICU2).

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