Timothy D. Girard

Oct 26, 2024 | bmjopen.bmj.com | Christina S. Boncyk |John Devlin |Hina Faisal |Timothy D. Girard

Methods and analysisTrial designINSPiRE-ICU1 is a phase 3, multicentre, randomised, controlled, open-label, assessor-blinded trial evaluating the efficacy and safety of inhaled isoflurane delivered via the Sedaconda ACD-S compared with intravenous propofol for the sedation of mechanically ventilated adults ICU patients. INSPiRE-ICU1 is the first of two, methodologically identical, parallel phase 3 trials (INSPiRE-ICU1 and INSPiRE-ICU2).

Feb 7, 2023 | scholarsarchive.byu.edu | Alessandro Morandi |Timothy D. Girard |Kristen Mirkle |James Jackson

AbstractPurposeWe undertook this pilot prospective cohort investigation to examine the feasibility of functional magnetic resonance imaging (fMRI) assessments in survivors of critical illness and to analyze potential associations between delirium and brain activation patterns observed during a working memory task (N-back) at hospital discharge and 3-month follow-up. Materials and methodsAt hospital discharge and 3 months later, fMRI assessed subjects' functional activity during an N-back task.

Jan 25, 2023 | thelancet.com | Timothy D. Girard |Pratik P. Pandharipande

Improvements in the acute management of critically ill patients have contributed to increased survival in the intensive care unit (ICU), yet up to two-thirds of survivors after mechanical ventilation struggle with post-intensive care syndrome, which consists of new or worsened cognitive impairment, physical disability, or mental health disorders.