Christopher Barrington

Jan 1, 2025 | nature.com | Leo Speidel |Marina Silva |Thomas Booth |Ben Raffield |Kyriaki Anastasiadou |Christopher Barrington

AbstractMany known and unknown historical events have remained below detection thresholds of genetic studies because subtle ancestry changes are challenging to reconstruct. Methods based on shared haplotypes1,2 and rare variants3,4 improve power but are not explicitly temporal and have not been possible to adopt in unbiased ancestry models.

Jan 10, 2024 | nature.com | Kyriaki Anastasiadou |Marina Silva |Thomas C Booth |Christopher Barrington |Pooja Swali |Ian Armit | +4 more

AbstractAncient DNA is a valuable tool for investigating genetic and evolutionary history that can also provide detailed profiles of the lives of ancient individuals. In this study, we develop a generalised computational approach to detect aneuploidies (atypical autosomal and sex chromosome karyotypes) in the ancient genetic record and distinguish such karyotypes from contamination. We confirm that aneuploidies can be detected even in low-coverage genomes ( ~ 0.0001-fold), common in ancient DNA.