Chrysostomos Perdios

Jan 8, 2025 | biorxiv.org | Chrysostomos Perdios |Naveen Babu |Anna Brown |Celeste D Coleman

AbstractCytomegalovirus (CMV) is a prevalent β-herpesvirus that persists asymptomatically in immunocompetent hosts. In people with HIV-1 (PWH), CMV is associated with persistence of the HIV-1 reservoir and particular inflammatory related co-morbidities. The true causative role of CMV in HIV-associated pathologies remains unclear given that nearly all PWH are coinfected with CMV.

Aug 20, 2024 | nature.com | Clovis S. Palmer |Chrysostomos Perdios |Mohamed Abdel-Mohsen |Nicholas J. Maness |Nadia Golden |Kelsey Williams | +4 more

AbstractHyperglycemia, and exacerbation of pre-existing deficits in glucose metabolism, are manifestations of the post-acute sequelae of SARS-CoV-2. Our understanding of metabolic decline after acute COVID-19 remains unclear due to the lack of animal models. Here, we report a non-human primate model of metabolic post-acute sequelae of SARS-CoV-2 using SARS-CoV-2 infected African green monkeys.

Sep 25, 2023 | biorxiv.org | Clovis S. Palmer |Mohamed Abdel-Mohsen |Joseph Mudd |Chrysostomos Perdios

AbstractHyperglycemia, and exacerbation of pre-existing deficits in glucose metabolism, are major manifestations of the post-acute sequelae of SARS-CoV-2 (PASC). Our understanding of lasting glucometabolic disruptions after acute COVID-19 remains unclear due to the lack of animal models for metabolic PASC. Here, we report a non-human primate model of metabolic PASC using SARS-CoV-2 infected African green monkeys (AGMs).