Mohamed Abdel-Mohsen

Aug 20, 2024 | nature.com | Clovis S. Palmer |Chrysostomos Perdios |Mohamed Abdel-Mohsen |Nicholas J. Maness |Nadia Golden |Kelsey Williams | +4 more

AbstractHyperglycemia, and exacerbation of pre-existing deficits in glucose metabolism, are manifestations of the post-acute sequelae of SARS-CoV-2. Our understanding of metabolic decline after acute COVID-19 remains unclear due to the lack of animal models. Here, we report a non-human primate model of metabolic post-acute sequelae of SARS-CoV-2 using SARS-CoV-2 infected African green monkeys.

Apr 1, 2024 | nature.com | Wei Zhou |Yuan Qi |Toshitha Kannan |Hiroaki Tateno |Daniel T. Claiborne |Mohamed Abdel-Mohsen

AbstractAberrant glycosylation is a crucial strategy employed by cancer cells to evade cellular immunity. However, it’s unclear whether homologous recombination (HR) status-dependent glycosylation can be therapeutically explored. Here, we show that the inhibition of branched N-glycans sensitizes HR-proficient, but not HR-deficient, epithelial ovarian cancers (EOCs) to immune checkpoint blockade (ICB).

Oct 2, 2023 | nature.com | Daniel Reeves |Mohamed Abdel-Mohsen |Mars Stone |Frederick M. Hecht |Jeffrey Martin |Steven Deeks | +2 more

AbstractPersistence of HIV in people living with HIV (PWH) on suppressive antiretroviral therapy (ART) has been linked to physiological mechanisms of CD4+ T cells. Here, in the same 37 male PWH on ART we measure longitudinal kinetics of HIV DNA and cell turnover rates in five CD4 cell subsets: naïve (TN), stem-cell- (TSCM), central- (TCM), transitional- (TTM), and effector-memory (TEM). HIV decreases in TTM and TEM but not in less-differentiated subsets.

Sep 25, 2023 | biorxiv.org | Clovis S. Palmer |Mohamed Abdel-Mohsen |Joseph Mudd |Chrysostomos Perdios

AbstractHyperglycemia, and exacerbation of pre-existing deficits in glucose metabolism, are major manifestations of the post-acute sequelae of SARS-CoV-2 (PASC). Our understanding of lasting glucometabolic disruptions after acute COVID-19 remains unclear due to the lack of animal models for metabolic PASC. Here, we report a non-human primate model of metabolic PASC using SARS-CoV-2 infected African green monkeys (AGMs).